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KMID : 0362220130400030241
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Journal of The Korean Research Society for Dental Materials
2013 Volume.40 No. 3 p.241 ~ p.246
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Effects of plasma surface modification to HA-coated titanium on preosteoblast adhesion and differentiation
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Lee Hyo-Jin
Son Jun-Sik
Kwon Tae-Yub
Kim Kho-Han
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Abstract
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Plasma technique has been proposed as a tool to produce a hydrophilic surface to hydroxyapatite (HA)-coated titanium, which is used as dental implant. The objective of this study was to evaluate the effect of plasma treated HA coated titanium on preosteoblast adhesion, proliferation and differentiation. The contact angle of plasma treated HA-coated titanium was lower than that of HA-coated titanium. Cells on HA-coated titanium and plasma treated HA-coated titanium spreaded and proliferated preosteoblast equally. But the MC3T3-E1 preosteoblast cells cultured on plasma treated HA-coated titanium enhanced the ALP activity and the expression of osteocalcin and osteopontin gene. The result demonstrated that atmospheric plasma decreased the contact angle of HA-coated titanium surface and promoted the differentiation of the MC3T3-E1 osteoblast cell by enhancing ALP activity, osteocalcin and osteopontin gene expression.
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KEYWORD
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Plasma, HA-coated Titanium, Contact angle, Preosteoblast, Adhesion, Differentiation
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